Typically, organizations lose around five percent of their revenue to fraud. In this presentation, we explore advanced AI techniques to address this issue. Drawing on our recent research, we begin by examining cost-sensitive fraud detection methods, such as CS-Logit which integrates the economic imbalances inherent in fraud detection into the optimization of AI models. We then move on to data engineering strategies that enhance the predictive capabilities of both the data and AI models through intelligent instance and feature engineering. We also delve into network data, showcasing our innovative research methods like Gotcha and CATCHM for effective data featurization. A significant focus is placed on Explainable AI (XAI), which demystifies high-performance AI models used in fraud detection, aiding in the development of effective fraud prevention strategies. We provide practical examples from various sectors including credit card fraud, anti-money laundering, insurance fraud, tax evasion, and payment transaction fraud. Furthermore, we discuss the overarching issue of model risk, which encompasses everything from data input to AI model deployment. Throughout the presentation, the speaker will thoroughly discuss his recent research, conducted in partnership with leading global financial institutions such as BNP Paribas Fortis, Allianz, ING, and Ageas.