Battery diagnostics aims to monitor a lithium-ion battery’s state of health (SOH) by estimating its capacity and degradation parameters over the service life. The SOH estimation informs online maintenance/control decision making, all performed within a battery management system. This talk will first give an overview of battery degradation diagnostics and then discuss the long-term testing and methodology development efforts led by a team of researchers at Iowa State University and the University of Connecticut. An emphasis will be placed on physics-informed machine learning for degradation diagnostics. Methodologies will be demonstrated using an industry-relevant application on implantable-grade lithium-ion batteries.